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Heart, Lung and Circulation

Relationship of Haptoglobin Phenotypes With Sarcopaenia in Patients With Congestive Heart Failure

Published:February 15, 2022DOI:https://doi.org/10.1016/j.hlc.2022.01.003

      Background

      Systemic inflammation in patients with chronic heart failure (CHF) contributes to age-related muscle loss or sarcopaenia. However, the relationship of plasma haptoglobin (Hp), an acute-phase reactant, with muscle and physical health in CHF is unknown.

      Methods

      This study investigated the associations of plasma haptoglobin levels and phenotypes with handgrip strength (HGS), appendicular skeletal muscle index (ASMI) and physical capacity in healthy controls (n=67) and CHF patients (n=61) aged 55–73 years.

      Results

      Patients with CHF had higher plasma Hp levels and higher proportions of Hp2-2 phenotype when compared with healthy controls. Plasma Hp2-1 and Hp2-2 levels were negatively associated with HGS and ASMI in healthy controls and CHF (both p<0.05). A negative association of plasma Hp2-2 with gait speed and plasma Hp2-1 with daily steps count was also found in CHF (p<0.05). Patients with Hp2 phenotype showed higher expressions of inflammation and oxidative stress markers, as well as low scores on quality of life parameters.

      Conclusions

      Circulating Hp may be a valuable biomarker for assessing muscle health and physical capacity in CHF.

      Central Illustration

      Keywords

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      References

        • Scharf G.
        • Heineke J.
        Finding good biomarkers for sarcopenia.
        J Cachexia Sarcopenia Muscle. 2012; 3: 145-148
        • Casati M.
        • Saul Costa A.
        • Capitanio D.
        • Ponzoni L.
        • Ferri E.
        • Agostini S.
        • et al.
        The biological foundations of sarcopenia: established and promising markers.
        Front Med (Lausanne). 2019; 6: 184
        • Drey M.
        Sarcopenia - pathophysiology and clinical relevance.
        Wien Med Wochenschr. 2011; 161: 402-408
        • Fülster S.
        • Tacke M.
        • Sandek A.
        • Ebner M.
        • Tschöpe C.
        • Doehner W.
        • et al.
        Muscle wasting in patients with chronic heart failure: results from the studies investigating co-morbidities aggravating heart failure (SICA-HF).
        Eur Heart J. 2013; 34: 512-519
        • Yin J.
        • Lu X.
        • Qian Z.
        • Xu W.
        • Zhou X.
        New insights into the pathogenesis and treatment of sarcopenia in chronic heart failure.
        Theranostics. 2019; 9: 4019-4029
        • Qaisar R.
        • Karim A.
        • Muhammad T.
        • Shah I.
        • Khan J.
        Prediction of sarcopenia using a battery of circulating biomarkers.
        Sci Rep. 2021; 11: 8632
        • Qaisar R.
        • Karim A.
        • Muhammed T.
        • Shah I.
        • Khan J.
        Circulating MicroRNAs as biomarkers of accelerated sarcopenia in chronic heart failure.
        Glob Heart. 2021; 16: 56
        • Shamsi K.S.
        • Pierce A.
        • Ashton A.S.
        • Halade D.G.
        • Richardson A.
        • Espinoza S.E.
        Proteomic screening of glycoproteins in human plasma for frailty biomarkers.
        J Gerontol A Biol Sci Med Sci. 2012; 67: 853-864
        • Walston J.
        • McBurnie M.A.
        • Newman A.
        • Tracy R.P.
        • Kop W.J.
        • Hirsch C.H.
        • et al.
        Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study.
        Arch Intern Med. 2002; 162: 2333-2341
        • Ding J.
        • Kopchick J.J.
        Plasma biomarkers of mouse aging.
        Age (Dordr). 2011; 33: 291-307
        • Byerley L.O.
        • Leamy L.
        • Tam S.W.
        • Chou C.-W.
        • Ravussin E.
        • Louisianna Healthy Aging Study
        Development of a serum profile for healthy aging.
        Age (Dordr). 2010; 32: 497-507
        • Murphy S.
        • Dowling P.
        • Zweyer M.
        • Henry M.
        • Meleady P.
        • Mundeger R.R.
        • et al.
        Proteomic profiling of mdx-4cv serum reveals highly elevated levels of the inflammation-induced plasma marker haptoglobin in muscular dystrophy.
        Int J Mol Med. 2017; 39: 1357-1370
        • Suleiman M.
        • Aronson D.
        • Asleh R.
        • Kapeliovich M.R.
        • Roguin A.
        • Meisel S.R.
        • et al.
        Haptoglobin polymorphism predicts 30-day mortality and heart failure in patients with diabetes and acute myocardial infarction.
        Diabetes. 2005; 54: 2802-2806
        • Lee P.L.
        • Lee K.Y.
        • Cheng S.M.
        • Chuang H.C.
        • Wu S.M.
        • Feng P.H.
        • et al.
        Relationships of haptoglobin phenotypes with systemic inflammation and the severity of chronic obstructive pulmonary disease.
        Sci Rep. 2019; 9: 189
        • Sonati V.P.
        Polymorphism of human haptoglobin and its clinical importance.
        Genet Mol Biol. 2008; 31
        • Steinbeck L.
        • Ebner N.
        • Valentova M.
        • Bekfani T.
        • Elsner S.
        • Dahinden P.
        • et al.
        Detection of muscle wasting in patients with chronic heart failure using C-terminal agrin fragment: results from the Studies Investigating Co-morbidities Aggravating Heart Failure (SICA-HF).
        Eur J Heart Fail. 2015; 17: 1283-1293
        • Qaisar R.
        • Karim A.
        • Muhammad T.
        • Shah I.
        • Iqbal M.S.
        The coupling between sarcopenia and COVID-19 is the real problem.
        Eur J Intern Med. 2021; 93: 105-106
        • Rabin R.
        • de Charro F.
        EQ-5D: a measure of health status from the EuroQol Group.
        Ann Med. 2001; 33: 337-343
        • World Medical A.
        World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects.
        JAMA. 2013; 310: 2191-2194
        • Qaisar R.
        • Karim A.
        • Muhammad T.
        Circulating biomarkers of handgrip strength and lung function in chronic obstructive pulmonary disease.
        Int J Chron Obstruct Pulmon Dis. 2020; 15: 311-321
        • Qaisar R.
        • Karim A.
        • Muhammad T.
        Plasma CAF22 levels as a useful predictor of muscle health in patients with chronic obstructive pulmonary disease.
        Biology (Basel). 2020; 9
        • Qaisar R.
        • Qayum M.
        • Muhammad T.
        Reduced sarcoplasmic reticulum Ca(2+) ATPase activity underlies skeletal muscle wasting in asthma.
        Life Sci. 2021; 273: 119296
        • Landi F.
        • Russo A.
        • Cesari M.
        • Pahor M.
        • Bernabei R.
        • Onder G.
        HDL-cholesterol and physical performance: results from the ageing and longevity study in the sirente geographic area (ilSIRENTE Study).
        Age Ageing. 2007; 36: 514-520
        • Gurung R.L.
        • Yiamunaa M.
        • Liu S.
        • Liu J.J.
        • Chan C.
        • Wai Munn Choo R.
        • et al.
        Association of haptoglobin phenotype with incident acute myocardial infarction in Chinese patients with type 2 diabetes.
        Cardiovasc Diabetol. 2019; 18: 65
        • Karim A.
        • Muhammad T.
        • Ustrana S.
        • Qaiser R.
        Intestinal permeability marker zonulin as a predictor of sarcopenia in chronic obstructive pulmonary disease.
        Respir Med. 2021; 189: 106662
        • Karim A.
        • Muhammad T.
        • Qaisar R.
        Prediction of sarcopenia using multiple biomarkers of neuromuscular junction degeneration in chronic obstructive pulmonary disease.
        J Pers Med. 2021; 11
        • Qaisar R.
        • Bhaskaran S.
        • Ranjit R.
        • Sataranatarajan K.
        • Premkumar P.
        • Huseman K.
        • et al.
        Restoration of SERCA ATPase prevents oxidative stress-related muscle atrophy and weakness.
        Redox Biol. 2019; 20: 68-74
        • Qaisar R.
        • Ustrana S.
        • Muhammad T.
        • Shah I.
        Sarcopenia in pulmonary diseases is associated with elevated sarcoplasmic reticulum stress and myonuclear disorganization.
        Histochem Cell Biol. 2021; 157: 93-105
        • Maggio M.
        • Ceda G.P.
        • Ticinesi A.
        • De Vita F.
        • Gelmini G.
        • Costantino C.
        • et al.
        Instrumental and non-instrumental evaluation of 4-meter walking speed in older individuals.
        PLoS One. 2016; 11e0153583
        • Oikawa S.Y.
        • Holloway T.M.
        • Phillips S.M.
        The impact of step reduction on muscle health in aging: protein and exercise as countermeasures.
        Front Nutr. 2019; 6: 75
        • Chiellini C.
        • Santini F.
        • Marsili A.
        • Berti P.
        • Bertacca A.
        • Pelosini C.
        • et al.
        Serum haptoglobin: a novel marker of adiposity in humans.
        J Clin Endocrinol Metab. 2004; 89: 2678-2683
        • Wang Y.
        • Kinzie E.
        • Berger F.G.
        • Lim S.K.
        • Baumann H.
        Haptoglobin, an inflammation-inducible plasma protein.
        Redox Rep. 2001; 6: 379-385
        • Marques L.P.
        • Confortin S.C.
        • Ono L.M.
        • Barbosa A.R.
        • d'Orsi E.
        Quality of life associated with handgrip strength and sarcopenia: EpiFloripa Aging Study.
        Arch Gerontol Geriatr. 2019; 81: 234-239
        • Dyer M.T.
        • Goldsmith K.A.
        • Sharples L.S.
        • Buxton M.J.
        A review of health utilities using the EQ-5D in studies of cardiovascular disease.
        Health Qual Life Outcomes. 2010; 8: 13
        • Rajendiran K.S.
        • Ananthanarayanan R.H.
        • Satheesh S.
        • Rajappa A.
        Elevated levels of serum sialic acid and high-sensitivity C-reactive protein: markers of systemic inflammation in patients with chronic heart failure.
        Br J Biomed Sci. 2014; 71: 29-32
        • Sadrzadeh S.M.
        • Bozorgmehr J.
        Haptoglobin phenotypes in health and disorders.
        Am J Clin Pathol. 2004; 121 Suppl: S97-S104
        • Muller F.L.
        • Song W.
        • Jang Y.C.
        • Liu Y.
        • Sabia M.
        • Richardson A.
        • et al.
        Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production.
        Am J Physiol Regul Integr Comp Physiol. 2007; 293: R1159-R1168
        • Qaisar R.
        • Karim A.
        • Elmoselhi A.B.
        Muscle unloading: A comparison between spaceflight and ground-based models.
        Acta Physiol (Oxf). 2020; 228e13431
        • Perez-Sousa M.A.
        • Venegas-Sanabria L.C.
        • Chavarro-Carvajal D.A.
        • Cano-Gutierrez C.A.
        • Izquierdo M.
        • Correa-Bautista J.E.
        • et al.
        Gait speed as a mediator of the effect of sarcopenia on dependency in activities of daily living.
        J Cachexia Sarcopenia Muscle. 2019; 10: 1009-1015
        • Tsekoura M.
        • Kastrinis A.
        • Katsoulaki M.
        • Billis E.
        • Gliatis J.
        Sarcopenia and its impact on quality of life.
        Adv Exp Med Biol. 2017; 987: 213-218
        • Boczor S.
        • Daubmann A.
        • Eisele M.
        • Blozik E.
        • Scherer M.
        Quality of life assessment in patients with heart failure: validity of the German version of the generic EQ-5D-5L.
        BMC Public Health. 2019; 19: 1464
        • Lee J.H.
        • Joo Y.B.
        • Han M.
        • Kwon S.R.
        • Park W.
        • Park K.-S.
        • et al.
        Relationship between oxidative balance score and quality of life in patients with osteoarthritis: Data from the Korea National Health and Nutrition Examination Survey (2014–2015).
        Medicine (Baltimore). 2019; 98e16355
        • Curcio F.
        • Testa G.
        • Liuori I.
        • Papillo M.
        • Flocco V.
        • Panicara V.
        • et al.
        Sarcopenia and heart failure.
        Nutrients. 2020; 12
        • Harris-Love M.O.
        • Benson K.
        • Leasure E.
        • Adams B.
        • McIntosh V.
        The Influence of upper and lower extremity strength on performance-based sarcopenia assessment tests.
        J Funct Morphol Kinesiol. 2018; 3
        • Curcio F.
        • Ferro G.
        • Basile C.
        • Liguori I.
        • Parrella P.
        • Pirozzi F.
        • et al.
        Biomarkers in sarcopenia: A multifactorial approach.
        Exp Gerontol. 2016; 85: 1-8