Background
Systemic inflammation in patients with chronic heart failure (CHF) contributes to
age-related muscle loss or sarcopaenia. However, the relationship of plasma haptoglobin
(Hp), an acute-phase reactant, with muscle and physical health in CHF is unknown.
Methods
This study investigated the associations of plasma haptoglobin levels and phenotypes
with handgrip strength (HGS), appendicular skeletal muscle index (ASMI) and physical
capacity in healthy controls (n=67) and CHF patients (n=61) aged 55–73 years.
Results
Patients with CHF had higher plasma Hp levels and higher proportions of Hp2-2 phenotype
when compared with healthy controls. Plasma Hp2-1 and Hp2-2 levels were negatively
associated with HGS and ASMI in healthy controls and CHF (both p<0.05). A negative
association of plasma Hp2-2 with gait speed and plasma Hp2-1 with daily steps count
was also found in CHF (p<0.05). Patients with Hp2 phenotype showed higher expressions
of inflammation and oxidative stress markers, as well as low scores on quality of
life parameters.
Conclusions
Circulating Hp may be a valuable biomarker for assessing muscle health and physical
capacity in CHF.
Central Illustration
Keywords
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Article info
Publication history
Published online: February 15, 2022
Accepted:
January 16,
2022
Received in revised form:
December 28,
2021
Received:
August 28,
2021
Identification
Copyright
© 2022 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
