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Heart, Lung and Circulation

A Diagnosis That a Cardiologist Should Not MIS: Multisystem Inflammatory Syndrome in Adults

Published:September 21, 2022DOI:https://doi.org/10.1016/j.hlc.2022.08.014
      Multisystem inflammatory syndrome in adults (MIS-A) is a newly recognised hyperinflammatory condition which has been discovered and defined during the COVID pandemic [
      • Patel P.
      • DeCuir J.
      • Abrams J.
      • Campbell A.P.
      • Godfred-Cato S.
      • Belay E.D.
      Clinical characteristics of multisystem inflammatory syndrome in adults.
      ]. It is characterised by persistent fever, elevated markers of inflammation, severe cardiac illness, and multiorgan dysfunction which develops in the weeks following the resolution of a COVID infection [

      Multisystem Inflammatory Syndrome in Adults (MIS-A) Case Definition Information for Healthcare Providers [Internet]. [cited 2022 Apr 6]; Available from: https://www.cdc.gov/mis/mis-a/hcp.html#:∼:text=Case%20Definition%20for%20MIS%2DA&text=Subjective%20fever%20or%20documented%20fever,first%20THREE%20days%20of%20hospitalization∗.

      ]. The cardiac abnormalities which can develop in MIS-A include myocarditis, pericarditis, coronary artery dilatation/aneurysm, new-onset right or left ventricular dysfunction, second and third degree atrio-ventricular (A-V) block, or ventricular tachycardia.

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      1. Multisystem Inflammatory Syndrome in Adults (MIS-A) Case Definition Information for Healthcare Providers [Internet]. [cited 2022 Apr 6]; Available from: https://www.cdc.gov/mis/mis-a/hcp.html#:∼:text=Case%20Definition%20for%20MIS%2DA&text=Subjective%20fever%20or%20documented%20fever,first%20THREE%20days%20of%20hospitalization∗.

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