Aim
Bone marrow-derived mesenchymal stem cells (BM-MSCs) are the most well-studied and
characterised stem cell types. This review was undertaken of the current available
phase II/III randomised clinical trials (RCTs) that delivered BM-MSCs to treat patients
with cardiomyopathy, and to assess their performance.
Methods
The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines
were followed during the systematic review and meta-analysis. Eligible studies were
reviewed, and their data charted. To assess the efficacy of BM-MSCs, the outcome was
improvement in left ventricular ejection fraction (LVEF) and 6-minute walking distance
(6MWD).
Results
The pooled weighted mean difference (WMD) showed that BM-MSCs treatment improved the
6MWD by 27.86 m (95% CI 0.11–55.6 m) compared with the control groups. The pooled
WMD showed that BM-MSCs treatment improved the LVEF by 6.37% (95% CI 5.48%–7.26%)
compared with the control groups.
Conclusion
BM-MSCs treatment is an effective intervention for managing patients with heart failure,
but it requires larger and more robust clinical trials to support its routine use
in clinics.
Keywords
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Article info
Publication history
Published online: March 03, 2023
Accepted:
January 2,
2023
Received in revised form:
December 22,
2022
Received:
June 22,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2023 Australian and New Zealand Society of Cardiac and Thoracic Surgeons (ANZSCTS) and the Cardiac Society of Australia and New Zealand (CSANZ). Published by Elsevier B.V. All rights reserved.
