Advertisement
Heart, Lung and Circulation
Original Article|Articles in Press

Synchronous Carotid Endarterectomy and Anaortic Off-Pump Coronary Artery Bypass Surgery

Published:March 10, 2023DOI:https://doi.org/10.1016/j.hlc.2023.01.014

      Background

      There is ongoing debate regarding the optimal strategy and timing for the surgical management of patients with severe concomitant carotid and coronary artery disease. Anaortic off-pump coronary artery bypass (anOPCAB), which avoids aortic manipulation and cardiopulmonary bypass, has been shown to reduce the risk of perioperative stroke. We present the outcomes of a series of synchronous carotid endarterectomy (CEA) and anOPCAB.

      Methods

      A retrospective review was performed. The primary endpoint was stroke at 30 days post-operation. Secondary endpoints included transient ischaemic attack, myocardial infarction and mortality 30 days post-operation.

      Results

      From 2009 to 2016, 1,041 patients underwent anOPCAB with a 30-day stroke rate of 0.4%. The majority of patients had preoperative carotid-subclavian duplex ultrasound screening and 39 were identified with significant concomitant carotid disease who underwent synchronous CEA-anOPCAB. The mean age was 71±7.5 years. Nine patients (23.1%) had previous neurological events. Thirty (30) patients (76.9%) underwent an urgent operation. For CEA, a conventional longitudinal carotid endarterectomy with patch angioplasty was performed in all patients. For anOPCAB, total arterial revascularisation rate was performed in 84.6% and the mean number of distal anastomoses was 2.9±0.7. In the 30-day postoperative period, there was one stroke (2.63%), two deaths (5.26%), two transient ischemic attacks (TIAs) (5.26%) and no myocardial infarction. Two patients experienced acute kidney injury (5.26%), one of which required haemodialysis (2.63%). Mean length of stay was 11.37±7.9 days.

      Conclusion

      Synchronous CEA and anOPCAB is a safe and effective option for patients’ severe concomitant disease. Preoperative carotid-subclavian ultrasound screening allows identification of these patients.

      Keywords

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Heart, Lung and Circulation
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Lazar H.L.
        • Menzoian J.O.
        Coronary artery bypass grafting in patients with cerebrovascular disease.
        Ann Thorac Surg. 1998; 66: 968-974
        • Poi M.J.
        • Echeverria A.
        • Lin P.H.
        Contemporary management of patients with concomitant coronary and carotid artery disease.
        World J Surg. 2018; 42: 272-282
        • Roffi M.
        • Ribichini F.
        • Castriota F.
        • Cremonesi A.
        Management of combined severe carotid and coronary artery disease.
        Curr Cardiol Rep. 2012; 14: 125-134
        • Naylor A.R.
        • Mehta Z.
        • Rothwell P.M.
        • Bell P.R.
        Carotid artery disease and stroke during coronary artery bypass: a critical review of the literature.
        Eur J Vasc Endovasc Surg. 2002; 23: 283-294
        • Borger M.A.
        • Fremes S.E.
        • Weisel R.D.
        • Cohen G.
        • Rao V.
        • Lindsay T.F.
        • et al.
        Coronary bypass and carotid endarterectomy: does a combined approach increase risk? A meta-analysis.
        Ann Thorac Surg. 1999; 68: 14-20
        • Djaiani G.N.
        Aortic arch atheroma: stroke reduction in cardiac surgical patients.
        Semin Cardiothorac Vasc Anesth. 2006; 10: 143-157
        • Charlson M.E.
        • Peterson J.C.
        • Krieger K.H.
        • Hartman G.S.
        • Hollenberg J.P.
        • Briggs W.M.
        • et al.
        Improvement of outcomes after coronary artery bypass II: a randomized trial comparing intraoperative high versus customized mean arterial pressure.
        J Card Surg. 2007; 22: 465-472
        • Zhao D.F.
        • Edelman J.J.
        • Seco M.
        • Bannon P.G.
        • Wilson M.K.
        • Byrom M.J.
        • et al.
        coronary artery bypass grafting with and without manipulation of the ascending aorta: a network meta-analysis.
        J Am Coll Cardiol. 2017; 69: 924-936
      1. https://anzscts.org/database/about/#DDM

        • Ramponi F.
        • Seco M.
        • Edelman J.B.
        • Sherrah A.G.
        • Bannon P.G.
        • Brereton R.J.L.
        • et al.
        Dual inflow, total-arterial, anaortic, off-pump coronary artery bypass grafting: how to do it.
        Ann Cardiothorac Surg. 2018; 7: 552-560
        • Kwak Y.L.
        • Oh Y.J.
        • Kim S.H.
        • Kim S.H.
        • Shin H.K.
        • Kim J.Y.
        • et al.
        Efficacy of pre-emptive milrinone in off-pump coronary artery bypass surgery: comparison between patients with a low and normal pre-graft cardiac index.
        Eur J Cardiothorac Surg. 2004; 26: 687-693
        • Na S.
        • Oh Y.J.
        • Shim Y.H.
        • Hong Y.W.
        • Bang S.O.
        • Kwak Y.L.
        Effects of milrinone on blood flow of the Y-graft composed with the radial and the internal thoracic artery in patients with coronary artery disease.
        Eur J Cardiothorac Surg. 2006; 30: 324-328
        • Buxton B.F.
        • Hayward P.A.
        The art of arterial revascularization-total arterial revascularization in patients with triple vessel coronary artery disease.
        Ann Cardiothorac Surg. 2013; 2: 543-551
        • Lev-Ran O.
        • Paz Y.
        • Pevni D.
        • Kramer A.
        • Shapira I.
        • Locker C.
        • et al.
        Bilateral internal thoracic artery grafting: midterm results of composite versus in situ crossover graft.
        Ann Thorac Surg. 2002; 74 (discussion 710-1): 704-710
        • Tarakji K.G.
        • Sabik J.F.
        • Bhudia S.K.
        • Batizy L.H.
        • Blackstone E.H.
        Temporal onset, risk factors, and outcomes associated with stroke after coronary artery bypass grafting.
        JAMA. 2011; 305: 381-390
        • Devgun J.K.
        • Gul S.
        • Mohananey D.
        • Jones B.M.
        • Hussain M.S.
        • Jobanputra Y.
        • et al.
        Cerebrovascular events after cardiovascular procedures: risk factors, recognition, and prevention strategies.
        J Am Coll Cardiol. 2018; 71: 1910-1920
        • Mao Z.
        • Zhong X.
        • Yin J.
        • Zhao Z.
        • Hu X.
        • Hackett M.L.
        Predictors associated with stroke after coronary artery bypass grafting: a systematic review.
        J Neurol Sci. 2015; 357: 1-7
        • Naylor A.R.
        • Mehta Z.
        • Rothwell P.M.
        • Bell P.R.
        Carotid artery disease and stroke during coronary artery bypass: a critical review of the literature.
        Eur J Vasc Endovasc Surg. 2002; 23: 283-294
        • Schwartz L.B.
        • Bridgman A.H.
        • Kieffer R.W.
        • Wilcox R.A.
        • McCann R.L.
        • Tawil M.P.
        • et al.
        Asymptomatic carotid artery stenosis and stroke in patients undergoing cardiopulmonary bypass.
        J Vasc Surg. 1995; 21: 146-153
        • Berens E.S.
        • Kouchoukos N.T.
        • Murphy S.F.
        • Wareing T.H.
        Preoperative carotid artery screening in elderly patients undergoing cardiac surgery.
        J Vasc Surg. 1992; 15: 313-321
        • Urbinati S.
        • Di Pasquale G.
        • Andreoli A.
        • Lusa A.M.
        • Carini G.
        • Grazi P.
        • et al.
        Preoperative noninvasive coronary risk stratification in candidates for carotid endarterectomy.
        Stroke. 1994; 25: 2022-2027
        • Jones E.L.
        • Craver J.M.
        • Michalik R.A.
        • Murphy D.A.
        • Guyton R.A.
        • Bone D.K.
        • et al.
        Combined carotid and coronary operations: when are they necessary?.
        J Thorac Cardiovasc Surg. 1984; 87: 7-16
        • Katz E.S.
        • Tunick P.A.
        • Rusinek H.
        • Ribakove G.
        • Spencer F.C.
        • Kronzon I.
        Protruding aortic atheromas predict stroke in elderly patients undergoing cardiopulmonary bypass: experience with intraoperative transesophageal echocardiography.
        J Am Coll Cardiol. 1992; 20: 70-77
        • Sen S.
        • Wu K.
        • McNamara R.
        • Lima J.
        • Piantadosi S.
        • Oppenheimer S.M.
        Distribution, severity and risk factors for aortic atherosclerosis in cerebral ischemia.
        Cerebrovasc Dis. 2000; 10: 102-109
        • Naylor A.R.
        • Bown M.J.
        Stroke after cardiac surgery and its association with asymptomatic carotid disease: an updated systematic review and meta-analysis.
        Eur J Vasc Endovasc Surg. 2011; 41: 607-624
        • Naylor A.R.
        • Cuffe R.L.
        • Rothwell P.M.
        • Bell P.R.
        A systematic review of outcomes following staged and synchronous carotid endarterectomy and coronary artery bypass.
        Eur J Vasc Endovasc Surg. 2003; 25: 380-389
        • Ramponi F.
        • Seco M.
        • Brereton R.J.L.
        • Gaudino M.F.L.
        • Puskas J.D.
        • Calafiore A.M.
        • et al.
        Toward stroke-free coronary surgery: The role of the anaortic off-pump bypass technique.
        J Card Surg. 2021; 36: 1499-1510
        • Moss E.
        • Puskas J.D.
        • Thourani V.H.
        • Kilgo P.
        • Chen E.P.
        • Leshnower B.G.
        • et al.
        Avoiding aortic clamping during coronary artery bypass grafting reduces postoperative stroke.
        J Thorac Cardiovasc Surg. 2015; 149: 175-180
        • Neumann F.J.
        • Sousa-Uva M.
        • Ahlsson A.
        • Alfonso F.
        • Banning A.P.
        • Benedetto U.
        • et al.
        ESC/EACTS Guidelines on myocardial revascularization.
        Eur Heart J. 2019; 40: 87-165
        • Lawton J.S.
        • Tamis-Holland J.E.
        • Bangalore S.
        • Bates E.R.
        • Beckie T.M.
        • Bischoff J.M.
        • et al.
        2021 ACC/AHA/SCAI Guideline for coronary artery revascularization: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
        J Am Coll Cardiol. 2022; 79: e21-e129
        • Whitlock R.P.
        • Belley-Cote E.P.
        • Paparella D.
        • Healey J.S.
        • Brady K.
        • Sharma M.
        • et al.
        Left atrial appendage occlusion during cardiac surgery to prevent stroke.
        N Engl J Med. 2021; 384: 2081-2091
        • Meharwal Z.S.
        • Mishra A.
        • Trehan N.
        Safety and efficacy of one stage off-pump coronary artery operation and carotid endarterectomy.
        Ann Thorac Surg. 2002; 73: 793-797
        • Beauford R.B.
        • Saunders C.R.
        • Goldstein D.J.
        Off pump concomitant coronary revascularization and carotid endarterectomy.
        J Cardiovasc Surg (Torino). 2003; 44: 407-415
        • Borioni R.
        • Weltert L.
        • De Paulis R.
        • Bellisario A.
        • Maselli D.
        • Tomai F.
        • et al.
        Early results of synchronous carotid endarterectomy and off-pump coronary revascularization.
        J Cardiovasc Surg (Torino). 2012; 53: 363-367
        • Fareed K.R.
        • Rothwell P.M.
        • Mehta Z.
        • Naylor A.R.
        Synchronous carotid endarterectomy and off-pump coronary bypass: an updated, systematic review of early outcomes.
        Eur J Vasc Endovasc Surg. 2009; 37: 375-378
        • Gopaldas R.R.
        • Chu D.
        • Dao T.K.
        • Huh J.
        • LeMaire S.A.
        • Lin P.
        • et al.
        Staged versus synchronous carotid endarterectomy and coronary artery bypass grafting: analysis of 10-year nationwide outcomes.
        Ann Thorac Surg. 2011; 91 (discussion 1329): 1323-1329